The objective of this research is to reconstruct the recent Holocene history of Cupressus sempervirens from the Bronze to the Roman Age in Italy. Our work consisted both in a review of published data and in the identification of novel archaeobotanical remains stored in the deposits of the National Archaeological Museum of Naples and of the Archaeological Park of Pompeii. The literature permitted to collect information linked to different plant remain typologies of the Italian cypress; 362 botanical remains were counted, of which 292 were from the Vesuvian area and 70 from other archaeological sites of the central and western Mediterranean. Data chronology spans from the second century BC to the AD fifth century for the archaeological area of ancient Campania and from the 14th century BC to the AD fourth century for the sites located in different regions. It is clear that the ‘cypress culture’ is confirmed by the archaeobotanical data found in the Roman world. Romans especially appreciated its timber but cypress was also used for many other purposes. Furthermore, the employment of timber for wells was documented in pre-Roman sites and the presence of fruits/seeds in central Italy confirms its importance also in the Bronze Age.