In this article it is argued that long-term economic growth can be secured by the continual re-invention of the technological and consequential economic bases of local economies. Starting from the perspective of evolutionary path dependence in the development histories of new technologies, the roles of innovators in the creation of new technological pathways are theorised. Historical case study evidence is then presented of the contributions of pioneering innovators to the ongoing long-term production and employment growth in the local economy of Oxfordshire over the last two centuries. Oxfordshire provides an empirical example of one of the more successful local economies in the UK. It is concluded that much of this success has been based on the activities of a small number of innovators who have used national and international knowledge networks to import cutting edge technologies of their time into the local economy in order to start world leading industries in the County. These have formed the bases of its long-term economic performance.